Although scientific research and publishing in the field of phototherapy become very fruitful in last two decades, we still don’t have critical mass of scientific articles that can finally brake a wall between LED phototherapy device producers and end users, physicians.

Please find here scientific articles that provide evidence of confirmed Body Boost Bed technology, divided in the groups according to CE certificated indications:

Circulation disorder including wound healing:

  1. Minatel DG, Frade MA, França SC, Enwemeka CS.Phototherapy promotes healing of chronic diabetic leg ulcers that failed to respond to other therapies.Lasers Surg Med. 2009 Aug;41(6):433-41.
  2. Igor Frangež,Ksenija Cankar, Helena Ban Frangež,Dragica Maja Smrke/ The effect of LED on blood microcirculation during chronic wound healing in diabetic and non-diabetic patients—a prospective, double-blind randomized study/ Lasers Med Sci (2017) 32:887–894; DOI 10.1007/s10103-017-2189-7
  3. Igor Frangež,Tea Nizič -Kos, Helena Ban Frangež/ Phototherapy with LED Shows Promising Results in Healing Chronic Wounds in Diabetes Mellitus Patients: A Prospective Randomized Double-Blind Study/ Photomedicine and Laser Surgery Volume 36, Number 7, 2018, Pp. 377–382,DOI: 10.1089/pho.2017.4382
  4. Paolillo FR, Corazza AV, Borghi-Silva A, Parizotto NA, Kurachi C, Bagnato VS. /Infrared LED irradiation applied during high-intensity treadmill training improves maximal exercise tolerance in postmenopausal women: a 6-month longitudinal study./ Lasers Med Sci. 2013 Feb;28(2):415-22. doi: 10.1007/s10103-012-1062-y. Epub 2012 Mar 2.
  5. Paolillo FR, Corazza AV, Paolillo AR, Borghi-Silva A, Arena R, Kurachi C, Bagnato VS. / Phototherapy during treadmill training improves quadriceps performance in postmenopausal women / Climacteric 2014 Jun;17(3):285-93. doi: 10.3109/13697137.2013.828196. Epub 2013 Sep 3.
  6. Borsa PA, Larkin KA, True JM.Does phototherapy enhance skeletal muscle contractile function and postexercise recovery? A systematic review.J Athl Train. 2013 Jan-Feb;48(1):57-67. doi: 10.4085/1062-6050-48.1.12. Review.
  7. Mak MC, Cheing GL.Immediate effects of monochromatic infrared energy on microcirculation in healthy subjects.Photomed Laser Surg. 2012 Apr;30(4):193-9. doi: 10.1089/pho.2011.3012.
  8. Leal Junior EC1, de Godoi V, Mancalossi JL, Rossi RP, De Marchi T, Parente M, Grosselli D, Generosi RA, Basso M, Frigo L, Tomazoni SS, Bjordal JM, Lopes-Martins RA. Comparison between cold water immersion therapy (CWIT) and light emitting diode therapy (LEDT) in short-term skeletal muscle recovery after high-intensity exercise in athletes–preliminary results.Lasers Med Sci. 2011 Jul;26(4):493-501. doi: 10.1007/s10103-010-0866-x. Epub 2010 Nov 19.
  9. Leal Junior EC, Lopes-Martins RA, Rossi RP, De Marchi T,Baroni BM, de Godoi V, Marcos RL, Ramos L, Bjordal JM. Effect of Cluster Multi-Diode Light Emitting Diode Therapy(LEDT) on Exercise-Induced Skeletal Muscle Fatigue and Skeletal Muscle Recovery in Humans. Lasers in Surgery and Medicine 41:572–577 (2009)
  10. Lima AC, Fernandes GA, de Barros Araújo R, Gonzaga IC, de Oliveira RA, Nicolau RA.Photobiomodulation (Laser and LED) on Sternotomy Healing in Hyperglycemic and Normoglycemic Patients Who Underwent Coronary Bypass Surgery with Internal Mammary Artery Grafts: A Randomized, Double-Blind Study with Follow-Up. Photomed Laser Surg. 2017
  11. de Oliveira RA, Fernandes GA, Lima AC, Tajra Filho AD, de Barros Araújo R Jr, Nicolau RA.The effects of LED emissions on sternotomy incision repair after myocardial revascularization: a randomized double-blind study with follow-up.Lasers Med Sci. 2014 May;29(3):1195-202.
  12. Oh IY, Kim BJ, Kim MN, Kim CW, Kim SE.Efficacy of light-emitting diode photomodulation in reducing erythema after fractional carbon dioxide laser resurfacing: a pilot study.Dermatol Surg. 2013 Aug;39(8):1171-6.
  13. Chaves ME, Araújo AR, Santos SF, Pinotti M, Oliveira LS.LED phototherapy improves healing of nipple trauma: a pilot study.Photomed Laser Surg. 2012 Mar;30(3):172-8.

Pain (muscular and joint pain):

  1. Lima AC, Fernandes GA, de Barros Araújo R, Gonzaga IC, de Oliveira RA, Nicolau RA.Photobiomodulation (Laser and LED) on Sternotomy Healing in Hyperglycemic and Normoglycemic Patients Who Underwent Coronary Bypass Surgery with Internal Mammary Artery Grafts: A Randomized, Double-Blind Study with Follow-Up. Photomed Laser Surg. 2017
  2. Higgins PE, Hews K, Windon L 3rd, Chasse P.Light-Emitting Diode Versus Sham in the Treatment of Plantar Fasciitis: A Randomized Trial.J Chiropr Med. 2015 Mar;14(1):10-4. doi: 10.1016/j.jcm.2014.12.004.
  3. de Oliveira RA, Fernandes GA, Lima AC, Tajra Filho AD, de Barros Araújo R Jr, Nicolau RA.The effects of LED emissions on sternotomy incision repair after myocardial revascularization: a randomized double-blind study with follow-up.Lasers Med Sci. 2014 May;29(3):1195-202.
  4. Minatel DG, Frade MA, França SC, Enwemeka CS.Phototherapy promotes healing of chronic diabetic leg ulcers that failed to respond to other therapies.Lasers Surg Med. 2009 Aug;41(6):433-41.
  5. Panhoca VH, Lizarelli Rde F, Nunez SC, Pizzo RC, Grecco C, Paolillo FR, Bagnato VS.Comparative clinical study of light analgesic effect on temporomandibular disorder (TMD) using red and infrared led therapy.Lasers Med Sci. 2015 Feb;30(2):815-22. doi: 10.1007/s10103-013-1444-9.
  6. Esper MA, Nicolau RA, Arisawa EA.The effect of two phototherapy protocols on pain control in orthodontic procedure–a preliminary clinical study.Lasers Med Sci. 2011 Sep;26(5):657-63. doi: 10.1007/s10103-011-0938-6.
  7. Chaves ME, Araújo AR, Santos SF, Pinotti M, Oliveira LS.LED phototherapy improves healing of nipple trauma: a pilot study.Photomed Laser Surg. 2012 Mar;30(3):172-8.
  8. John Foley, David B Vasily, Jeanna Bradle,Catharine Rudio and R Glen Calderhead / 830 nm light-emitting diode (led) phototherapy significantly reduced return-to-play in injured university athletes: a pilot study/ Laser Ther. 2016 Mar 31;25(1):35-42

Lines and wrinkles:

  1. Calderhead RG, Vasily DB.Low Level Light Therapy with Light-Emitting Diodes for the Aging Face.Clin Plast Surg. 2016 Jul;43(3):541-50. doi: 10.1016/j.cps.2016.03.011. Review.
  2. Greaves AJ.The effects of narrowbands of visible light upon some skin disorders: a review.Int J Cosmet Sci. 2016 Aug;38(4):325-45. doi: 10.1111/ics.12305. Review.
  3. A. Wunsch and K. Matuschka: A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase; Photomed Laser Surg. 2014 Feb 1;32(2): 93–100.doi: 10.1089/pho.2013.3616
  4. Gold MH.Light-emitting diode.Curr Probl Dermatol. 2011;42:173-80. doi: 10.1159/000328326.
  5. Kim WS, Calderhead RG.Is light-emitting diode phototherapy (LED-LLLT) really effective?Laser Ther. 2011;20(3):205-15. Review.
  6. Migliardi R, Tofani F, Donati L.Non-invasive peri-orbital rejuvenation: radiofrequency dual radiowave energy source (RF) and light emission diode system (LED).Orbit. 2009;28(4):214-8.
  7. Barolet D, Roberge CJ, Auger FA, Boucher A, Germain L.Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: clinical correlation with a single-blinded study.J Invest Dermatol. 2009 Dec;129(12):2751-9. doi: 10.1038/jid.2009.186.
  8. Sadick NS.A study to determine the efficacy of a novel handheld light-emitting diode device in the treatment of photoaged skin.J Cosmet Dermatol. 2008 Dec;7(4):263-7. doi: 10.1111/j.1473-2165.2008.00404.x.
  9. Baez F, Reilly LR.The use of light-emitting diode therapy in the treatment of photoaged skin.J Cosmet Dermatol. 2007 Sep;6(3):189-94.

10. Lee SY, Park KH, Choi JW, Kwon JK, Lee DR, Shin MS, Lee JS, You CE, Park MY.A prospective, randomized, placebo-controlled, double-blinded, and split-face                              clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three                  different treatment settings.J Photochem Photobiol B. 2007 Jul 27;88(1):51-67.